diff --git a/runelite-client/src/main/java/net/runelite/client/config/RuneLiteConfig.java b/runelite-client/src/main/java/net/runelite/client/config/RuneLiteConfig.java
index c0ca0bf929..fd88f334b5 100644
--- a/runelite-client/src/main/java/net/runelite/client/config/RuneLiteConfig.java
+++ b/runelite-client/src/main/java/net/runelite/client/config/RuneLiteConfig.java
@@ -430,4 +430,16 @@ public interface RuneLiteConfig extends Config
 	{
 		return new Keybind(KeyEvent.VK_F12, InputEvent.CTRL_DOWN_MASK);
 	}
+
+	@ConfigItem(
+		keyName = "blockExtraMouseButtons",
+		name = "Block Extra Mouse Buttons",
+		description = "Blocks extra mouse buttons (4 and above)",
+		position = 34,
+		titleSection = "keybindsTitle"
+	)
+	default boolean blockExtraMouseButtons()
+	{
+		return false;
+	}
 }
diff --git a/runelite-client/src/main/java/net/runelite/client/input/MouseManager.java b/runelite-client/src/main/java/net/runelite/client/input/MouseManager.java
index 30f0d34c03..0357f4195d 100644
--- a/runelite-client/src/main/java/net/runelite/client/input/MouseManager.java
+++ b/runelite-client/src/main/java/net/runelite/client/input/MouseManager.java
@@ -28,14 +28,21 @@ import java.awt.event.MouseEvent;
 import java.awt.event.MouseWheelEvent;
 import java.util.List;
 import java.util.concurrent.CopyOnWriteArrayList;
+import javax.inject.Inject;
 import javax.inject.Singleton;
+import net.runelite.client.config.RuneLiteConfig;
 
 @Singleton
 public class MouseManager
 {
+	// Button numbers greater than BUTTON3 have no constant identifier
+	private static final int MOUSE_BUTTON_4 = 4;
 
 	private final List<MouseListener> mouseListeners = new CopyOnWriteArrayList<>();
 	private final List<MouseWheelListener> mouseWheelListeners = new CopyOnWriteArrayList<>();
+	
+	@Inject
+	private RuneLiteConfig runeLiteConfig;
 
 	public void registerMouseListener(MouseListener mouseListener)
 	{
@@ -75,6 +82,7 @@ public class MouseManager
 
 	public MouseEvent processMousePressed(MouseEvent mouseEvent)
 	{
+		checkExtraMouseButtons(mouseEvent);
 		for (MouseListener mouseListener : mouseListeners)
 		{
 			mouseEvent = mouseListener.mousePressed(mouseEvent);
@@ -84,6 +92,7 @@ public class MouseManager
 
 	public MouseEvent processMouseReleased(MouseEvent mouseEvent)
 	{
+		checkExtraMouseButtons(mouseEvent);
 		for (MouseListener mouseListener : mouseListeners)
 		{
 			mouseEvent = mouseListener.mouseReleased(mouseEvent);
@@ -93,12 +102,24 @@ public class MouseManager
 
 	public MouseEvent processMouseClicked(MouseEvent mouseEvent)
 	{
+		checkExtraMouseButtons(mouseEvent);
 		for (MouseListener mouseListener : mouseListeners)
 		{
 			mouseEvent = mouseListener.mouseClicked(mouseEvent);
 		}
 		return mouseEvent;
 	}
+	
+	private void checkExtraMouseButtons(MouseEvent mouseEvent)
+	{
+		// Prevent extra mouse buttons from being passed into the client,
+		// as it treats them all as left click
+		int button = mouseEvent.getButton();
+		if (button >= MOUSE_BUTTON_4 && runeLiteConfig.blockExtraMouseButtons())
+		{
+			mouseEvent.consume();
+		}
+	}
 
 	public MouseEvent processMouseEntered(MouseEvent mouseEvent)
 	{